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KMID : 0061119820100000066
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Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.66 ~ p.66
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Cochlear Pathology and Effects of Therapeutic Agents in Mercury Intoxication of Guinea Pigs
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Kim Hoon
Kim Byung-Woo
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Abstract
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1) The acute inorganic mercury intoxication frequently induced mitochondrial changes of nerve endings and outer hair cells.
2) In chronic inorganic mercury intoxication, the significant damages of apical $´ hair cells were observed in cytocochleograms and also, dark degenerations of nerve terminals and changes of stria vascularis were observed by electron microscopy,
3) The effect of 2,3-dimercaptopropanol on the cochlea was not significant in acute and chronic inorganic mercury intoxications.
4) D-penicillamine was significantly effective in reducing cochlear pathology, when it was given very shortly after mercuric chloride administration.
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